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HPV infection dramatically increases the diversity of the vaginal microbiome, leading to a gradual increase in the abundance of anaerobic bacteria and the severity of cervical dysplasia. Any unnecessary surgical treatment for cervical dysplasia could negatively affect obstetric outcomes and sex life. Assessment of the local immune and microbial environment could improve medical care in patients with CIN and cervical cancer.

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Erik Kudela, Alena Liskova, Marek Samec, Lenka Koklesova, Veronika Holubekova, Tomas Rokos, Erik Kozubik, Terezia Pribulova, Kevin Zhai, Dietrich Busselberg, Peter Kubatka & Kamil Biringer (2021)

The interplay between the vaginal microbiome and innate immunity in the focus of predictive, preventive, and personalized medical approach to combat HPV-induced cervical cancer. EPMA Journal. ➡ Display this record
➡ evidence-based medicine/midwifery ; guidelines ; public health ; prevention ; HPV human papillomavirus ; vaginal microbiota

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