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https://ciane.net/id=923

Created on : 07 Oct 2004
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

The endocrinology of parturition in the human. Baillieres Clin Endocrinol Metab 1990 Jun;4(2):333-49

Author(s) :

Steer PJ.

Year of publication :

1992

URL(s) :

Résumé (français)  :

Abstract (English)  :

Current evidence suggests that oestrogens, progesterone, relaxin, the prostaglandins, and oxytocin are all hormones concerned to a major degree with the onset and maintenance of parturition. Oestrogens, relaxin, and the prostaglandins are particularly involved with cervical ripening, while prostaglandins, progesterone and oxytocin are more involved in regulating myometrial contractility. Catecholamines may also have some regulatory function in relation to uterine contractions. Progesterone dominance during pregnancy is associated with a firm closed cervix, few myometrial gap junctions, low calcium levels in the cells, and a quiescent myometrium. At term, a change in the oestrogen/progesterone balance favours cervical ripening and increased uterine activity. Of particular importance at the level of the muscle cell are changes in the number of oxytocin receptors; a complex interaction between cAMP and phosphoinositide metabolism governs the intracellular level of calcium, thus regulating contractile activity.

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Resumen (español)  :

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Keywords :

➡ hormones ; oxytocin ; pain

Author of this record :

Bernard Bel — 07 Oct 2004