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Created on : 30 Jun 2004
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Nitric oxide donors: effects on fetoplacental blood flow. European Journal of Obstetrics & Gynecology and Reproductive Biology 2004;115(1):10-14.

Author(s) :

Kähler C, Schleußner E, Möller A, Seewald H-J.

Year of publication :

2004

URL(s) :

http://www.sciencedirect.com/science/article/B6T69…

Résumé (français)  :

Abstract (English)  :

OBJECTIVE: To investigate fetal and uteroplacental blood flow after transdermal administration of glyceroltrinitrate (GTN) in pregnancies at risk for preterm delivery.

STUDY DESIGN: Twenty-five pregnant women who received GTN patches (Nitroderm TTS 10®) with a dosage of 0.8 mg/h, because of risk for preterm delivery, were included in the prospective study. Doppler measurements (resistance index, RI) of the umbilical artery (UA), the middle cerebral artery (MCA) and the uterine arteries of the placental (UTA-P) and the non-placental (UTA-NP) side, with calculation of the mean-RI (UTA-mean), were performed before and after 24, 48 and 72 h of the 1st GTN application. Wilcoxon test and Holm correction were used for statistical analysis.

RESULTS: The initial RI values were in the normal range. Significant decreases of the RI of UTA-NP (P=0.02) and UTA-mean (P=0.03) were observed 24 h after GTN application. The other RI values did not show significant changes.

CONCLUSION: Transdermal nitroglycerine used for the treatment of preterm labour does only reduce uterine vascular impedance at the non-placental side with primary higher resistance. It does not affect fetal perfusion and uterine perfusion at the placental side with normal blood flow resistance.

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Keywords :

➡ premature baby

Author of this record :

Cécile Loup — 30 Jun 2004