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Created on : 29 Mar 2006
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Use of misoprostol for cervical ripening. {USA}. South Med J. 2000 Sep;93(9):881-4.

Author(s) :

Katz VL, Farmer RM, Dean CA, Carpenter ME.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :

BACKGROUND: Misoprostol, the prostaglandin E1 analog, is increasingly used for cervical ripening and induction of labor. We evaluated our experience with misoprostol in an open-label setting.

METHODS: Patients were selected for cervical ripening based on clinical profile. At 3 cm cervical dilation, misoprostol was discontinued and other means of labor augmentation were used. Over 13 months, 470 inductions of labor occurred, and 455 charts were available; 254 patients (56%) received misoprostol for cervical ripening, and 144 (32%) received dinoprostone (prostaglandin E2).

RESULTS: With misoprostol, mean time from beginning of contractions until delivery was 7 hours, 30 minutes; vaginal birth occurred in 85% of cases, and spontaneous labor occurred in 38%. Hyperstimulation occurred in 4 cases (1.6%) and precipitate labor in 7 (3%). All infants were discharged in excellent condition; one had a 5-minute Apgar score <7, and 33 (13%) had meconium, none with aspiration. Twenty-three patients who had had a previous cesarean section received misoprostol and delivered vaginally.

CONCLUSION: Misoprostol was found to be a safe and effective agent for cervical ripening as part of labor induction.

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Keywords :

➡ vaginal birth after caesarean ; evidence-based medicine/midwifery ; c-section/caesarean ; induction of labor ; ripening of cervix ; misoprostol (Cytotec) ; post-term pregnancy ; dilation

Author of this record :

Cécile Loup — 29 Mar 2006
➡ latest update : Bernard Bel — 02 Dec 2007

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