Base de données - (CIANE)

Présentation de cette base de données documentaires (site du CIANE)
Actuellement 3111 fiches
➡ Chaîne YouTube (tutoriel)

https://ciane.net/id=746

Créée le : 29 Apr 2004
Modifiée le : 01 Dec 2007

➡ Modifier cette fiche
Ne suivez ce lien que si vous possédez un mot de passe d’éditeur !

Notice bibliographique (sans auteurs) :

Different levels of platelet activation in preeclamptic, normotensive pregnant, and nonpregnant women. American Journal of Obstetrics and Gynecology 2004;190(4):1128-1134.

Auteur·e(s) :

Holthe MR, Staff AC, Berge LN, Lyberg T.

Année de publication :

2004

URL(s) :

http://www.sciencedirect.com/science/article/B6W9P…

Résumé (français)  :

Abstract (English)  :

Objective

The aims of our study were to determine the basal platelet activation state in women with preeclampsia compared with normotensive pregnant women and nonpregnant women and to investigate the platelet reactivity on in vitro stimulation with adenosine diphosphate or thrombin receptor activation peptide.
Study design

Platelet expression of CD61 (fibrinogen receptor), CD42a (von Willebrand factor receptor), CD62P (P-selectin), CD63 (Glycoprotein 53), and PAC-1 binding (activated fibrinogen receptor) were determined in 20 pairs of women with preeclampsia/normotensive pregnant women and in 12 nonpregnant women, with the use of flow cytometry.
Results

Basal platelet expression of CD61, CD42a and CD62P, and adenosine diphosphate–stimulated CD62P expression were increased in women with preeclampsia compared with normotensive pregnant women. Platelets from women with preeclampsia and normotensive pregnant women differed from platelets from nonpregnant women by expressing higher basal CD63 levels and being more responsive to in vitro agonist stimulation, which was demonstrated by increased expression of CD61, CD62P, and CD63.
Conclusion

This study supports the notion that platelets are important in the pathophysiologic condition of preeclampsia.

Sumário (português)  :

Resumen (español)  :

Remarques :

Argument (français) :

Argument (English):

Argumento (português):

Argumento (español):

Mots-clés :

➡ éclampsie (pré-)

Auteur·e de cette fiche :

Cécile Loup — 29 Apr 2004