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Créée le : 13 Apr 2004
Modifiée le : 02 Dec 2007

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Does the route of administration of misoprostol make a difference? The uterotonic effect and side effects of misoprostol given by different routes after vaginal delivery. Review. European Journal of Obstetrics & Gynecology and Reproductive Biology 2004;113(2):191-198.

Auteur·e(s) :

Chong YS, Chua S, Shen L, Arulkumaran S.

Année de publication :

2004

URL(s) :

http://www.sciencedirect.com.gate4.inist.fr/scienc…

Résumé (français)  :

Abstract (English)  :

OBJECTIVE: To compare the postpartum uterotonic effect and side effects of misoprostol administered by different routes.

STUDY DESIGN: Fifty women were given misoprostol 400 g either by the oral solution, oral tablet, rectal or vaginal route, or intramuscular syntometrine 1 ml after spontaneous vaginal delivery. Pre- and post-treatment uterine activity were measured with intrauterine pressure catheters.

RESULTS: Uterine activity produced by oral solution misoprostol 400 g was significantly higher than that of oral tablet, rectal and vaginal misoprostol (P=0.045, 0.004, 0.002, respectively). Onset of action after oral solution misoprostol was faster than by the oral tablet (P=0.01), rectal (P<0.001) and vaginal (P<0.001) routes. Shivering and pyrexia were most common with oral solution misoprostol. Maximum body temperature recorded was significantly higher with oral solution misoprostol than with oral tablet, rectal and vaginal misoprostol (P=0.005, 0.009, 0.001, respectively).

CONCLUSION: Different routes of administering misoprostol greatly influence the effects achieved. Oral solution misoprostol produces the fastest and strongest uterotonic effect, with the most side effects.

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Resumen (español)  :

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Argumento (português):

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Mots-clés :

➡ durée du travail ; médecine factuelle ; déclenchement ; gestion active du travail ; hémorragie postpartum ; misoprostol (Cytotec) ; dépassement de terme

Auteur·e de cette fiche :

Cécile Loup — 13 Apr 2004