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Creado el : 11 Feb 2004
Alterado em : 01 Dec 2007

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Ficha bibliográfica (sin autores) :

Pre-eclampsia: a parent-offspring conflict. Personnal views. J Psychosom Obstet Gynecol 2000;21:179-182.

Autores :

Schuiling GA.

Año de publicación :

2002

URL(s) :

http://jpog.ispog.org/

Résumé (français)  :

Abstract (English)  :

Reproduction and selection are two sides of the same coin, the latter including mate selection, selection of the spermatozoön which will fertilize the (selected) oöcyte, selection of the zygote and selection of the fetus. ln this paper the principles underlying selection during pregnancy and its consequences for the development of pre- eclampsia are discussed. Pregnancy, it appears, has much in common with a host-parasite relationship, in which the host (the mother) and the parasite (the fetus) live together in a delicate equilibrium which is easily disturbed if one of the two parties does not react adequately to the presence of the other. Already during pregnancy, as during later phases of life, ’parent-offspring conflicts’ play a role; one of these conflicts concerns implantation of the blastocyst into the endometrium of the mother. This gives rise to a maternal inflammatory response which, if not adequately regulated by the fetus, may easily cause the latter’s elimination. lt is up to the fetus to demonstrate that it is fit enough to carry its genes into the next generation, in line with which view it is postulated that pre-eclampsia, which is always associated with pregnancy, might be the result of this conflict and that the disease presents when the fetus is not able to adequately control the maternal host-defence response without, however, being eliminated. Then the inflammatory response continues and a ’balance of terror’ ensues. In that situation the maternal inflammatory response threatens not only the life of the fetus but also that of the mother.

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Palabras claves :

➡ eclampsia (pre)

Autor de este registro :

Cécile Loup — 11 Feb 2004