Banco de dados - (CIANE)

Descrição deste banco de dados documental (Site da CIANE)
Atualmente 3111 fichas
➡ Canal do YouTube (tutorial)

https://ciane.net/id=2773

Criado em : 26 Nov 2017
Alterado em : 26 Nov 2017

➡ Modificar esta ficha
Siga este link somente se você tiver um palavra chave de editor!

Nota bibliográfica (sem autor) :

Evaluating misoprostol content in pregnant women with hourly oral administration during labor induction by microElution solid phase extraction combined with liquid chromatography tandem mass spectrometry - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences - Vol. 1000 - p.176-180

Autores :

Hung, C.-H.; Cheng, S.-Y.; Chan, T.-M.; Lee, M.-R.

Ano de publicação :

2015

URL(s) :

https://www.scopus.com/inward/record.uri?eid=2-s2.…
https://doi.org/10.1016/j.jchromb.2015.07.012

Résumé (français)  :

Abstract (English)  :

Misoprostol is a widely used alternative of prostaglandin for labor induction. Based on previous studies, we envision that small and frequent oral dosage of misoprostol is an effective method for labor induction. To monitor the misoprostol content during labor induction, a rapid, sensitive, and selective microElution solid phase extraction (μElution SPE) combined with liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed. Using μElution SPE could minimize the sample consumption and elution volume in order to maximize the sample enrichment and throughput. The misoprostol acid, a metabolite of misoprostol, was gradient separated in a Bidentate C18 column, then quantified by highly-selective reaction monitoring (H-SRM) in a total run time of 6. min. The developed method was optimized and validated in human plasma, and showed linear range of 0.01-10. ng/mL. The limit of detection (LOD) was 0.001. ng/mL. The recovery ranged from 89.0 to 96.0%, and no significant matrix effect or carryover was observed. The precision, accuracy and stability were met with the criteria of U.S. FDA guidance. The developed method was successfully applied to evaluate misoprostol concentration during labor induction in pregnant women. The concentration-time profiles approves that hourly oral administration of misoprostol is a safe and effective method without drug accumulation for labor induction. © 2015 Elsevier B.V.

Sumário (português)  :

Resumen (español)  :

Comentários :

Argument (français) :

Argument (English):

Argumento (português):

Argumento (español):

Palavras-chaves :

➡ indução ; misoprostol (Cytotec)

Autor da esta ficha :

Import 26/11/2017 — 26 Nov 2017