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Currently 3111 records
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Created on : 24 Dec 2008
Modified on : 29 Oct 2018

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Bibliographical entry (without author) :

Cell-free fetal DNA in maternal circulation after amniocentesis. Clin Chem 49:1193–1195.

Author(s) :

Samura O, et al.

Year of publication :

2003

URL(s) :

http://clinchem.aaccjnls.org/content/49/7/1193
https://doi.org/10.1373/49.7.1193

Résumé (français)  :

Abstract (English)  :

After amniocentesis, 5–20% of patients have evidence of fetal-maternal hemorrhage as indicated by increases in maternal serum α-fetoprotein (1)(2)(3)(4)(5) or by the Betke–Kleihauer test (6)(7)(8). The Betke–Kleihauer test can differentiate fetal from maternal erythrocytes by the relative resistance of hemoglobin F-containing cells to acid elution, and it is the most popular method of diagnosing and assessing the severity of fetal-maternal hemorrhage (9). The reliability of this test has been questioned, however, because numerous sources of error are associated with it (10). These sources of error possibly contribute to the wide variation in the reported incidence of fetal-maternal hemorrhage; a more accurate method of assessing fetal-maternal hemorrhage is therefore required in the clinical setting of rhesus D-negative pregnant women.

Sumário (português)  :

Resumen (español)  :

Full text (public) :

Comments :

Argument (français) :

L’amniocentèse perturbe considérablement l’interface mère-placenta; des études complémentaires sont nécessaires pour déterminer si l’ADN fœtal est un marqueur sensible des hémorragies materno-fœtales ou si son augmentation après l’amniocentèse reflète le transfert de l’ADN du liquide amniotique à la circulation maternelle.

Argument (English):

Amniocentesis significantly disturbs the maternal-placental interface; further studies are needed to determine whether fetal DNA is a sensitive marker for fetal-maternal hemorrhage or whether its increase after amniocentesis reflects transfer of DNA from amniotic fluid to the maternal circulation.

Argumento (português):

A amniocentese perturba significativamente a interface materno-placentária; mais estudos são necessários para determinar se o DNA fetal é um marcador sensível de hemorragia fetal-materna ou se seu aumento após a amniocentese reflete a transferência de DNA do líquido amniótico para a circulação materna.

Argumento (español):

Keywords :

➡ antenatal diagnosis

Author of this record :

Bernard Bel — 24 Dec 2008
➡ latest update : Bernard Bel — 29 Oct 2018