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Bibliographical entry (without author) : | Maternal obesity and risk of neural tube defects: a metaanalysis. American Journal of Obstetrics and Gynecology 2008;198(6):611-619. |
Author(s) : | S. A. Rasmussen, S. Y. Chu, S. Y. Kim, C. H. Schmid and J. Lau |
Year of publication : | 2008 |
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Résumé (français) : | Nous avons réalisé une méta-analyse des études publiées sur la relation entre l’obésité maternelle et le risque de défaut de fermeture du tube neural (NTDs). Les études pertinentes ont été identifiées à partir de trois sources : (1) une recherche dans PubMed des articles publiés entre janvier 1980 et janvier 2007, (2) des listes de références sélectionnées par PubMed, et (3) des listes de références d’articles de revue sur l’obésité et les conséquences maternelles publiées entre janvier 2000 et janvier 2007. Douze études remplissaient les critères de sélection. Un modèle bayésien a été utilisé pour la méta-analyse et la méta-régression. Les rapports de risque non ajustés pour des grossesses affectées par un NTDs étaient de 1.22 ((95% CI, 0.99-1.49), 1.70 (95% CI, 1.34-2.15), et 3.11 (95% CI, 1.75-5.46), pour les femmes en surpoids, obèses, et sévèrement obèses, respectivement, comparées à des femmes de poids normal. Aucune des caractéristiques inclues des les études n’affectait significativement les résultats de l’analyse statistique. L’obésité maternelle est associée à une augmentation du risque de défaut de fermeture du tube neural pendant la grossesse. |
Abstract (English) : | We conducted a metaanalysis of published evidence on the relationship between maternal obesity and the risk of neural tube defects (NTDs). Eligible studies were identified from 3 sources: (1) PubMed search of articles that were published from January 1980 through January 2007, (2) reference lists of publications that were selected from the PubMed search, and (3) reference lists of review articles on obesity and maternal outcomes that were published from January 2000 through January 2007. Twelve studies met inclusion criteria. A Bayesian random effects model was used for the metaanalysis and metaregression. Unadjusted odds ratios for an NTD-affected pregnancy were 1.22 (95% CI, 0.99-1.49), 1.70 (95% CI, 1.34-2.15), and 3.11 (95% CI, 1.75-5.46) among overweight, obese, and severely obese women, respectively, compared with normal-weight women. None of the study characteristics included in the metaregression analysis affected the results significantly. Maternal obesity is associated with an increased risk of an NTD-affected pregnancy. |
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Argument (français) : | L’obésité augmente le risque de défaut de fermeture du tube neural. |
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Author of this record : | Cécile Loup — 06 Jun 2008 |
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