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Créée le : 19 Feb 2008
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Median values and maternal weight specific to the ethnic group should be used BMJ, Apr 1996; 312: 1041

Auteur·e(s) :

Kevin Spencer

Année de publication :

1996

URL(s) :

http://www.bmj.com/cgi/content/extract/312/7037/10…

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Abstract (English)  :

EDITOR,--Lucy Gilbert and colleagues report a 3.5-fold increase in the proportion of women found to be positive on screening for Down’s syndrome when rates among Indian Asian women were compared with those among white women.1 This prompted me to examine the data from Oldchurch Hospital’s screening programme. Unlike Gilbert and colleagues’ study, this screening programme uses (alpha) fetoprotein and free ß human chorionic gonadotrophin as biochemical markers, a combination shown to give a detection rate of 75% at a false positive rate of 5%.2 Screening with this test combination has been carried out in my department since 1991, and over the past four years about 50000 women have been screened. Women are assigned to one of four ethnic groups: white, Afro-Caribbean, Asian, and oriental/others/unknown. Table 1 shows the breakdown of the screened population by ethnic group and and the proportion found to be positive.

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Emmanuelle Phan — 19 Feb 2008