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https://ciane.net/id=2028

Created on : 14 Apr 2007
Modified on : 15 Jul 2018

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Bibliographical entry (without author) :

Amniotic-fluid embolism and medical induction of labour: a retrospective, population-based cohort study. {Canada}. Lancet. 2006 Oct 21;368(9545):1399-401.

Author(s) :

Kramer MS, Rouleau J, Baskett TF, Joseph KS.

Year of publication :

2006

URL(s) :

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=p…

Résumé (français)  :

Abstract (English)  :

BACKGROUND: Amniotic-fluid embolism is a rare, but serious and often fatal maternal complication of delivery, of which the cause is unknown. We undertook an epidemiological study to investigate the association between amniotic-fluid embolism and medical induction of labour.

METHODS: We used a population-based cohort of 3 million hospital deliveries in Canada between 1991 and 2002 to assess the associations between overall and fatal rates of amniotic-fluid embolism and medical and surgical induction, maternal age, fetal presentation, mode of delivery, and pregnancy and labour complications.

FINDINGS: Total rate of amniotic-fluid embolism was 14.8 per 100,000 multiple-birth deliveries and 6.0 per 100,000 singleton deliveries (odds ratio 2.5 [95% CI 0.9-6.2]). Of the 180 cases of amniotic-fluid embolism in women with singleton deliveries during the study period, 24 (13%) were fatal. We saw no significant temporal increase in occurrence of amniotic-fluid embolism for total or fatal cases. Medical induction of labour nearly doubled the risk of overall cases of amniotic-fluid embolism (adjusted odds ratio 1.8 [1.3-2.7]), and the association was stronger for fatal cases (crude odds ratio 3.5 [1.5-8.4]). Maternal age of 35 years or older, caesarean or instrumental vaginal delivery, polyhydramnios, cervical laceration or uterine rupture, placenta previa or abruption, eclampsia, and fetal distress were also associated with an increased risk.

INTERPRETATION: Medical induction of labour seems to increase the risk of amniotic-fluid embolism. Although the absolute excess risk is low, women and physicians should be aware of this risk when making decisions about elective labour induction.

Sumário (português)  :

Resumen (español)  :

Full text (private) :

Comments :

Argument (français) :

L’embolie est rare, mais souvent mortelle. Le déclenchement de l’accouchement est associé à un risque deux fois plus élévé de survenue d’une embolie.

Argument (English):

Embolism is rare, but often fatal. The onset of delivery is associated with a risk twice as high of an embolism.

Argumento (português):

Embolia é rara, mas freqüentemente fatal. O início do parto está associado ao dobro do risco de embolia.

Argumento (español):

Keywords :

➡ placenta previa/accreta ; induction of labor ; post-term pregnancy ; eclampsia (pre-) ; instrumental delivery ; perinatal death rates

Author of this record :

Cécile Loup — 14 Apr 2007
➡ latest update : Bernard Bel — 15 Jul 2018