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Created on : 26 Oct 2005
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Oral misoprostol versus injectable methylergometrine in management of the third stage of labor.{Inde}. Int J Gynaecol Obstet. 2005 Nov;91(2):160-1.

Author(s) :

Garg P, Batra S, Gandhi G.

Year of publication :

2005

URL(s) :

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=…

Résumé (français)  :

Abstract (English)  :

Postpartum hemorrhage is the leading cause of maternal deaths in the developing world, accounting for 30% of such deaths in areas where maternal mortality is high; in the developed world, it is the cause of maternal deaths in less than 10% of births.
……
The present study was conducted in Lok Nayak Hospital, New Delhi, India during a 1-year period from 2002 to 2003. Two hundred pregnant women fulfilled the inclusion criteria, i.e. all primigravidas with singleton pregnancy who underwent normal vaginal delivery. These women were randomly allocated to either the (A) misoprostol (Misoprost-200, CIPLA, Boisar Road, Paighar, Thane) group, or (B) the control group receiving methylergometrine (Mem, Neon Laboratories, Virgonagar, Bangalore 560049) in a 1:1 ratio by random number sequence. Group A received 600 μg of misoprostol orally immediately after giving birth and after division of the umbilical cord. Group B received 0.2 mg of methylergometrine intravenously at delivery of the anterior shoulder of the infant.
…….
The results were comparable in both groups, except that shivering and fever occurred more frequently in the misoprostol group, but these effects were self-limiting.
…..
If misoprostol were made available to the trained birth attendants who supervise the majority of births in India, the lives of many women dying of atonic postpartum hemorrhage could be saved in that country. Thus, the advantages of oral misoprostol make it a feasible drug to be used in the routine management of the third stage of labor in developing countries.

Sumário (português)  :

Resumen (español)  :

Comments :

Argument (français) :

Gestion active du travail en Inde: une haute dose de misoprostol donnée systématiquement pour diminuer les hémorragies post-partum.

Argument (English):

Argumento (português):

Argumento (español):

Keywords :

➡ evidence-based medicine/midwifery ; duration of labour ; active management of labor ; postpartum hemorrhage ; misoprostol (Cytotec) ; induction of labor

Author of this record :

Cécile Loup — 26 Oct 2005
➡ latest update : Bernard Bel — 02 Dec 2007