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Created on : 24 Oct 2005
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort.{Norvège}. BMJ. 2005 Oct 15;331(7521):877.

Author(s) :

Skjaerven R, Vatten LJ, Wilcox AJ, Ronning T, Irgens LM, Lie RT.

Year of publication :

2005

URL(s) :

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=…

Résumé (français)  :

Abstract (English)  :

OBJECTIVES: To assess the impact on risk of pre-eclampsia of genes that work through the mother, and genes of paternal origin that work through the fetus.

DESIGN: Population based cohort study.

SETTING: Registry data from Norway.

PARTICIPANTS: Linked generational data from the medical birth registry of Norway (1967-2003): 438,597 mother-offspring units and 286,945 father-offspring units.

MAIN OUTCOME MEASURES: Pre-eclampsia in the second generation.

RESULTS: The daughters of women who had pre-eclampsia during pregnancy had more than twice the risk of pre-eclampsia themselves (odds ratio 2.2, 95% confidence interval 2.0 to 2.4) compared with other women. Men born after a pregnancy complicated by pre-eclampsia had a moderately increased risk of fathering a pre-eclamptic pregnancy (1.5, 1.3 to 1.7). Sisters of affected men or women, who were themselves born after pregnancies not complicated by pre-eclampsia, also had an increased risk (2.0, 1.7 to 2.3). Women and men born after pre-eclamptic pregnancies were more likely to trigger severe pre-eclampsia in their own (or their partner’s) pregnancy (3.0, 2.4 to 3.7, for mothers and 1.9, 1.4 to 2.5, for fathers).

CONCLUSIONS: Maternal genes and fetal genes from either the mother or father may trigger pre-eclampsia. The maternal association is stronger than the fetal association. The familial association predicts more severe pre-eclampsia.

Sumário (português)  :

Resumen (español)  :

Comments :

Argument (français) :

Mise en évidence de liens familiaux dans le risque de pré-éclampsie.

Argument (English):

Argumento (português):

Argumento (español):

Keywords :

➡ evidence-based medicine/midwifery ; eclampsia (pre-)

Author of this record :

Cécile Loup — 24 Oct 2005