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Created on : 22 Sep 2005
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Does maternal race or ethnicity affect the expression of severe preeclampsia? {USA}. American Journal of Obstetrics and Gynecology 2005;193(3 Suppl):973-8.

Author(s) :

Goodwin AA, Mercer BM.

Year of publication :

2005

URL(s) :

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=…

Résumé (français)  :

Abstract (English)  :

OBJECTIVE: There is considerable variation in the expression of severe preeclampsia. Our purpose was to determine if this is associated with maternal race or ethnicity.

STUDY DESIGN: Individual chart review was performed for women diagnosed with severe preeclampsia at a tertiary care center from 1993 to 2003. Demographic, clinical, and lab findings from diagnosis (Dx) to 6 weeks’ postpartum (PP) were documented. Data were compared between Caucasian, African American, and Hispanic women. Data were presented for the total cohort if no significant difference was found.

RESULTS: We evaluated 473 pregnancies: 201 (Caucasian), 216 (African American), and 56 (Hispanic). Groups had similar baseline characteristics: chronic hypertension (HTN), diabetes, and initial antenatal blood pressure (mean BP 118/68). Caucasian women were older (27 vs 24 yrs), more likely nulliparous (63 vs 49%), and had more multiple gestations (9 vs 1.5%), P < .002 for each. African Americans had less epigastric pain (7.4 vs 10%) and nausea (2.3 vs 5%), P < .05 for each. Platelets <100,000/muL and asparate aminotransferase >60 mg/dL were more common in Caucasian women at Dx (9 vs 12%, 11 vs 21%) and at delivery (14 vs 24%, 19 vs 34%), P < .05 for each. No difference in severe proteinuria was seen. African Americans had more severe HTN at both Dx (44.9 vs 30%) and peak BP (85 vs 67%), and required more antihypertensive Rx intrapartum (12 vs 6%), PP (38 vs 12%), and at discharge (35 vs. 21%), P < .03 for each. Hispanics presented later (36 vs 34.6 weeks) and had less severe HTN (27 vs 40%), P < .04 for each. BP on DC was not different between groups. Caucasian women had more hemolysis, elevated liver enzymes and low platelets syndrome (29 vs 19%, P=.01). Eclampsia, intrauterine fetal demise, intrauterine growth restriction, abruption, PP preeclampsia, and recurrent preeclampsia were similar between groups.

CONCLUSION: African American women with severe preeclampsia demonstrate more severe hypertension and required more antihypertensive Rx, while Caucasian women have more frequent hemolysis, elevated liver enzymes and low platelets syndrome.

Sumário (português)  :

Resumen (español)  :

Comments :

Argument (français) :

La pré-éclampsie sévère se manifeste par plus de syndromes HELLP chez les femmes caucasiennes, et par plus d’hypertension sévère chez les femmes africaines-américaines.

Argument (English):

Argumento (português):

Argumento (español):

Keywords :

➡ evidence-based medicine/midwifery ; eclampsia (pre-)

Author of this record :

Cécile Loup — 22 Sep 2005