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Created on : 24 May 2005
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Is maternal use of selective serotonin reuptake inhibitors in the third trimester of pregnancy harmful to neonates? Commentary. Canadian Medical Association Journal 2005;172(11):1457-1459.

Author(s) :

Koren G, Matsui D, Einarson A, Knoppert D, Steiner M.

Year of publication :

2005

URL(s) :

http://www.cmaj.ca/cgi/content/full/172/11/1457?et…

Résumé (français)  :

Abstract (English)  :

Last summer, the US Food and Drug Administration instructed manufacturers of antidepressants to issue warnings about perinatal complications associated with their products.1 Physicians were advised to taper the dosage of antidepressants in pregnant women during the last trimester so that the fetus receives no drug for at least 7–10 days before delivery. A month later, Health Canada followed suit; the Canadian advisory2 similarly suggested that "Physicians may consider slowly decreasing the dose of these medications in the third trimester." These advisories were based on "reports reveal[ing] that some newborns whose mothers took these medications during pregnancy have developed complications at birth."2 These complications were seen as consistent with withdrawal symptoms or a direct adverse effect by the antidepressant on the baby.

We believe those recommendations are only partially evidence-based and may put the depressed mother-to-be and her baby at an unreasonable health risk. This paper presents a brief discussion of the pattern of neonatal symptoms observed after maternal use of selective serotonin or serotonin– norepinephrine reuptake inhibitors (SSRIs or SNRIs, respectively).

Sumário (português)  :

Resumen (español)  :

Full text (private) :

Comments :

Texte en accès libre.

Argument (français) :

Femmes en dépression grave pendant la grossesse: il n’est pas certain que supprimer ou diminuer les
antidépresseurs pendant le 3e trimestre soit moins nocif pour le bébé que de les continuer.

Argument (English):

Argumento (português):

Argumento (español):

Keywords :

➡ depression, anxiety ; pathologies of newborn ; psychology

Author of this record :

Cécile Loup — 24 May 2005