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Creado el : 29 Apr 2005
Alterado em : 02 Dec 2007

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Ficha bibliográfica (sin autores) :

Antenatal Associations with Lung Maturation and Infection. Journal of Perinatology (2005) 25, S31-S35.

Autores :

Jobe AH.

Año de publicación :

2005

URL(s) :

http://www.nature.com/cgi-taf/DynaPage.taf?file=/j…

Résumé (français)  :

Abstract (English)  :

Chronic clinically unapparent chorioamnionitis is a common antenatal exposure for very preterm infants, and these infants have variable degrees of lung maturation and a high risk of developing bronchopulmonary dysplasia. Exposure of fetal sheep to intra-amniotic endotoxin or IL-1 induces chorioamnionitis and lung injury (decreased alveolarization and microvascular injury), which resolves to a phenotype of striking lung maturation (increased surfactant, improved gas exchange and lung mechanics). The immune responses of the fetus also are suppressed or induced (matured) in time and dose-dependent ways by either chorioamnionitis or antenatal corticosteroids. These experimental observations contribute to explanations of why preterm infants have variable degrees of lung maturation at birth and unpredictably develop bronchopulmonary dysplasia BPD.

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Palabras claves :

➡ infecciones ; prematuro

Autor de este registro :

Cécile Loup — 29 Apr 2005