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Currently 3109 records
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Created on : 16 Nov 2004
Modified on : 27 Dec 2007

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Bibliographical entry (without author) :

Antenatal screening for Down’s syndrome. Editorial. The British Medical Journal 2004;329:811-812.

Author(s) :

Alfirevic Z.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :

Initially, invasive testing was offered only to women over 35 years, but this identified only one third of fetuses with Down’s syndrome. Universal screening started with the observation that serum concentrations of fetoprotein, used to screen for neural tube defects, tended to be lower when the fetus had Down’s syndrome. Several other biochemical tests were combined with age related risk to calculate an individualised risk for Down’s syndrome. Anyone with a risk of 1:250 or greater was offered amniocentesis; others were reassured with a low risk result. Another breakthrough was the advent of screening for increased nuchal translucency, a fluid filled space behind the fetal neck, which tends to be more prominent in fetuses affected by Down’s syndrome between 10 and 13 weeks of pregnancy.1 Nuchal translucency screening allowed earlier testing, but required expertise and equipment not readily available.

Sumário (português)  :

Resumen (español)  :

Comments :

Argument (français) :

Detecter de façon sure la trisomie 21 en évitant l’amniocentèse.

Argument (English):

Argumento (português):

Argumento (español):

Keywords :

➡ evidence-based medicine/midwifery ; amniocentesis ; screening ; antenatal diagnosis ; ultrasound scanning ; trisomy

Author of this record :

Cécile Loup — 16 Nov 2004

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