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Created on : 22 Sep 2005
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

A sister’s risk: Family history as a predictor of preeclampsia. {USA}. American Journal of Obstetrics and Gynecology 2005;193(3):965-972.

Author(s) :

Carr DB, Epplein M, Johnson CO, Easterling TR, Critchlow CW.

Year of publication :

2005

URL(s) :

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=…

Résumé (français)  :

Abstract (English)  :

OBJECTIVE: The purpose of this study was to determine if women with preeclampsia are more likely to have a sister who also had preeclampsia.

STUDY DESIGN: This was a population-based case-control study using data from Washington (WA) state birth certificates linked to hospital discharge records. Cases were women with gestational hypertension (n = 1611) or preeclampsia (n = 1071); controls (n = 8041) had normotensive pregnancies. All women delivered their first child between 1987 to 2002 and had a sister with a previous delivery in WA.

RESULTS: Women with preeclampsia were 2.3 times (95%CI 1.8-2.9) more likely to have a sister who had preeclampsia; those with gestational hypertension were 1.6 times (95%CI 1.3-2.0) more likely to have a sister with gestational hypertension. Similar results were obtained following stratification by age, race, smoking status, or body mass index.

CONCLUSION: The greater likelihood of preeclampsia among sisters of women with a previous preeclamptic pregnancy is consistent with a pathophysiologic role for genetic and/or behavioral factors that cluster in families.

Sumário (português)  :

Resumen (español)  :

Comments :

Argument (français) :

Il existe un lien familial dans les facteurs de risque de la pré-éclampsie (génétique ou comportemental).

Argument (English):

Argumento (português):

Argumento (español):

Keywords :

➡ evidence-based medicine/midwifery ; eclampsia (pre-)

Author of this record :

Cécile Loup — 22 Sep 2005